Klamentin 1g

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Update date: 2014-04-24 10:07
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Function: Antiallergic Drugs Indication: Antibiotic Dosage Form: Film coated tablets Strength: Amoxicillin: 875 mg; Clavulanic acid ... Place of Origin: Vietnam Brand Name: Klamentin

composition, indications, contraindications, precautions, dosage & administration

composition:

amoxicillin  ........................... 875 mg

clavulanic acid ..................... 125 mg

excipients q.s....................... 1 tablet

(sodium starch glycolate, aerosil,  magnesium stearate, sepifilm)

dosage form:

film coated tablets.

presentation:

box of 2 blisters x 7 film coated tablets.

pharmacodynamics:

amoxicillin is a beta-lactam semi-synthetic antibiotic with a broad-spectrum of bactericial activity against many gram-positive and gram-negative microorganisms due to inhibition of bacterial cell wall synthesis. amoxicillin is, however, susceptible to degradation by beta - lactamases and, therefore, the spectrum of activity does not include organisms which produce these enzymes.

clavulanic acid has beta-lactam structure resembling that of penicillin. it is an inhibitor of beta-lactamases produced by gram-negative bacteria and staphylococcus.  clavulanic acid is particularly active against the plasmid medicated beta-lactamase frequently responsible for transferred drug resistance to penicillins and cephalosporins.

the combination of clavulanic acid and amoxicillin in klamentin helps to protect amoxicillin from degradation by beta-lactamase enzymes, and effectively extends the antibacterial spectrum of amoxicillin to include many bacteria normally resistant to amoxicillin and microorganisms resistant to other penicillins and cephalosporins.

pharmacokinetics:

amoxicillin and clavulanic acid are well absorbed by oral administration and achieve the maximum serum concentrations after 1 - 2 hours. absorption of klamentin is not affected by food; klamentin should be taken right before meals. oral bioavailability of amoxicillin is 90% and that of clavulanic acid is 75%. the serum half life of amoxicillin is 1 - 2 hours and that of clavulanic acid is about 1 hour. approximately 55% to 70% of the amoxicillin and approximately 30% to 40% of the clavulanic acid are excreted active in urine. concurrent administration of probenecid delays amoxicillin excretion but does not delay renal excretion of clavulanic acid.

indications:

for short-term treatment of infections of upper and lower respiratory tract, urogenital tract, skin and soft tissue, bone, and joint and other infections such as infected abortion, obstetric infections, abdominal infections.

klamentin is bactericidal to a variety of bacteria including beta-lactamase-producing microorganisms resistant to ampicillin and amoxicillin.

contraindications:

hypersensitivity to penicillins and cephalosporins.

severe hepatic and renal impairment.

a history of jaundice or hepatic dysfunction during receiving penicillin.

infectious mononucleosis.

precautions:

klamex is used with caution in pregnant women and nursing mothers.

the dose should be adjusted in renal-impaired patients.

prolonged use of klamentin is reported to cause superinfection.

interactions:

probenecid decreases renal tubular secretion of amoxicillin; thus, it may result in increased blood levels of amoxicillin.

klamentin may prolong the bleeding and clotting time.

klamentin may reduce the efficacy of oral contraceptives.

adverse effects:

gastrointestinal disturbances: diarrhoea, nausea, vomiting.

rarely: anaphylactic reaction, quincke oedema, thrombocytopenia, hypoleukemia, hemolytic anemia, pseudomembranous colitis, stevens-johnson syndrome.

inform your physician about any adverse effects occur during the treatment. 

overdosage:

following overdosage, klamentin rarely induces accidents because of its good absorption even high doses. however, acute reactions occurring depend on hypersensitive states in each individual. risk of hyperpotassemia is reported when using high doses since clavulanic acid is used in the form of potassium salts. both amoxicillin and clavunate are removed from the circulation by hemodialysis.

dosage & administration:

the doses are based on amoxicillin component. klamentin 1g should be taken immediately before meals to reduce the drug intolerance in the stomach and intestine. klamentin 1g is used in severe infections.

adults and children aged > 12 years take 1 tablet twice daily.

duration of therapy is 5 - 10 days and should not be exceeded 14 days without re-examination.

klamentin 1g should not be used in patients with medium renal impairment.

or as directed by the physician.

read the directions carefully before use.

consult the physician for more information.

this drug is for prescriptions only.

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